How Do You Spell CARBOXYPEPTIDASE N?

1. Carboxypeptidase N is an enzyme that belongs to the family of carboxypeptidases, which are responsible for catalyzing the hydrolysis of peptide bonds at the C-terminal end of proteins or peptides. It is also known as CPA-N or plasma carboxypeptidase B. Carboxypeptidase N specifically cleaves basic amino acids (lysine, arginine) from the C-terminal end of peptides.

   This enzyme is commonly found in various tissues and biological fluids, including the pancreas, liver, and blood plasma. In humans, carboxypeptidase N is primarily synthesized in the pancreas and released into the bloodstream. Its main function is the regulation of the levels of kinins, which are small peptides involved in the control of blood pressure and inflammation.

   The catalytic activity of carboxypeptidase N is dependent on different cofactors, including zinc ions, activating peptides, and calcium ions. It plays a crucial role in the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Additionally, carboxypeptidase N is involved in the degradation of various peptides, such as bradykinin, substance P, and neurotensin.

   Carboxypeptidase N is an essential component of the enzymatic network involved in the regulation of numerous physiological processes, including blood pressure, inflammation, and neuropeptide signaling. Its dysfunction or altered expression levels have been associated with several diseases, such as hypertension, cancer, and neurodegenerative disorders. Thus, carboxypeptidase N serves as an important target for therapeutic interventions aimed at modulating the activity of this enzyme for potential clinical applications.

Common Misspellings for CARBOXYPEPTIDASE N

The word "Carboxypeptidase" is derived from the combination of the terms "carboxy-" and "peptidase".

- "Carboxy-" comes from the Latin word "carboxylus", meaning "acid group". It refers to the carboxyl functional group (COOH) present in amino acids.

- "Peptidase" comes from the term "peptide" which originates from the French "peptique" and ultimately from the Greek word "peptos" meaning "digested". A peptidase is an enzyme that breaks down peptides.

The letter "N" is simply used as a distinguishing letter for this specific type of carboxypeptidase, and its exact etymology is not available.