Endothelial Cell Derived Growth Factors (EDGFs) are a group of proteins and peptides that are produced and released by endothelial cells, which are the cells that line the inner surface of blood vessels. These growth factors play a crucial role in regulating various physiological processes, such as angiogenesis (the formation of new blood vessels) and wound healing.
EDGFs are known to stimulate the proliferation and migration of endothelial cells, promoting the formation of new blood vessels. This is particularly important in situations where there is a need for increased blood supply, such as during tissue repair or in the growth of tumors.
Some common examples of EDGFs include vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-β). These factors can act on endothelial cells directly or indirectly through a cascade of signaling events, ultimately leading to the activation of genes involved in cell proliferation and migration.
In addition to their role in angiogenesis and wound healing, EDGFs are also involved in the regulation of vascular tone, permeability, and immune responses. Dysfunction or abnormal expression of EDGFs has been implicated in various pathological conditions, such as cancer, diabetic retinopathy, and inflammatory disorders.
Overall, endothelial cell derived growth factors are critical mediators of endothelial cell function and have significant implications in both normal physiology and disease processes.
