GLYOXALASE I Meaning and
Definition
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Glyoxalase I is an enzyme that plays a vital role in the glyoxalase system, a crucial pathway for the detoxification of methylglyoxal (MG) in living organisms. MG is a cytotoxic byproduct produced as a result of normal cellular metabolism and is primarily derived from the breakdown of glucose.
Glyoxalase I, also known as glyoxalase-1 or GLO1, is responsible for catalyzing the conversion of MG into D-lactate by utilizing glutathione as a cofactor. Glutathione, a potent antioxidant, actively participates in the glyoxalase pathway to neutralize the harmful effects of MG. The reaction catalyzed by Glyoxalase I is essentially a detoxification process that eliminates MG, preventing its accumulation and subsequent damage to cellular components.
The glyoxalase system, including Glyoxalase I, is present in virtually all organisms, from bacteria to humans. It is particularly important in mammalian cells due to their high glucose metabolism. Dysregulation or deficiency of Glyoxalase I has been linked to various pathological conditions such as diabetes, cancer, and neurodegenerative disorders. Thus, the enzyme plays a significant role in maintaining cellular health and preventing the accumulation of toxic metabolites.
In summary, Glyoxalase I is an enzyme involved in the detoxification of the cytotoxic metabolite MG. It catalyzes the conversion of MG to D-lactate, thereby preventing its accumulation and potential damage to cellular components.
Common Misspellings for GLYOXALASE I
- flyoxalase i
- vlyoxalase i
- blyoxalase i
- hlyoxalase i
- ylyoxalase i
- tlyoxalase i
- gkyoxalase i
- gpyoxalase i
- goyoxalase i
- gltoxalase i
- glgoxalase i
- glhoxalase i
- gluoxalase i
- gl7oxalase i
- gl6oxalase i
- glyixalase i
- glykxalase i
- glylxalase i
- glypxalase i
- gly0xalase i
Etymology of GLYOXALASE I
The word "Glyoxalase I" has an etymology rooted in the field of biochemistry and molecular biology.
The term "glyoxalase" originates from the combination of two words, glyoxal and -ase. Glyoxal is a chemical compound that is an intermediate in the breakdown of glucose and other sugars. The suffix "-ase" is commonly used in biochemistry to refer to an enzyme. Therefore, "glyoxalase" refers to an enzyme involved in the metabolism or breakdown of glyoxal.
The Roman numeral "I" indicates that Glyoxalase I is the first discovered or most prominent isoform of the glyoxalase enzyme. Isoforms are different forms or variations of a protein that perform the same or similar function in an organism.
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