GM ALLOTYPES Meaning and
Definition
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Gm allotypes refer to genetic variations or polymorphisms found in the constant (C) region of immunoglobulin G (IgG) antibodies. IgG antibodies are a type of antibody that is the most abundant in the human bloodstream and play a crucial role in the immune response. The constant region of IgG antibodies is responsible for the effector functions of these antibodies, such as complement activation and interaction with immune cells.
Gm allotypes are determined by different alleles of the immunoglobulin heavy chain γ (IGHG) genes. These genes are located on chromosome 14 and are involved in encoding the constant region of IgG antibodies. There are several Gm allotypes that can be identified by specific genetic markers or protein variants, which are inherited in a codominant manner.
The Gm allotypes are named based on a nomenclature system that includes a letter representing the heavy chain gene (G) and a small letter indicating the specific IgG subclass (m), followed by a number representing the allele. For example, G1m is an allotype of the IgG1 subclass, and G3m is an allotype of the IgG3 subclass.
Gm allotypes have been extensively studied due to their potential association with various diseases and immune responses. Differences in Gm allotypes can influence the binding and clearance of antibodies, as well as their ability to activate complement and interact with immune cells. Therefore, understanding Gm allotypes is important in the field of immunogenetics and can provide insights into the role of IgG antibodies in health and disease.
Common Misspellings for GM ALLOTYPES
- fm allotypes
- vm allotypes
- bm allotypes
- hm allotypes
- ym allotypes
- tm allotypes
- gn allotypes
- gk allotypes
- gj allotypes
- gm zllotypes
- gm sllotypes
- gm wllotypes
- gm qllotypes
- gm aklotypes
- gm aplotypes
- gm aolotypes
- gm alkotypes
- gm alpotypes
- gm alootypes
- gm allitypes
Etymology of GM ALLOTYPES
The term Gm Allotypes does not have a specific etymology as it is a scientific term used in immunogenetics and immunology. It refers to genetic variations of gamma (G) immunoglobulins (antibodies) in human blood plasma. The Gm stands for gamma chain marker. These allotypes are identified by specific genetic markers and are used to classify different types of gamma globulins. The word itself is a combination of the abbreviation Gm and the term allotypes.
