SCID HU MICE Meaning and
Definition
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SCID hu mice, also known as SCID humanized mice, are a specialized strain of laboratory mice that have been genetically modified to possess a condition called severe combined immunodeficiency (SCID). The mice also possess components of a human immune system, making them a valuable tool in medical research for studying human diseases, immune responses, and testing potential treatments.
Severe combined immunodeficiency refers to a group of rare genetic disorders characterized by a severely weakened or absent immune system. In SCID hu mice, this condition is induced through genetic manipulation, resulting in the impaired functioning of the mouse's immune system. This makes the mice highly susceptible to infections and unable to mount effective immune responses.
To overcome this deficit, human immune cells or human hematopoietic stem cells are introduced into the SCID hu mice. These cells engraft and develop, allowing the mice to possess a functional human immune system alongside their compromised mouse immune system. This unique combination enables researchers to study how the human immune system responds to various pathogens, diseases, and therapies in an in vivo setting.
SCID hu mice provide an important model for understanding the intricate workings of the human immune system, as well as for evaluating the safety and efficacy of novel immunotherapies or potential vaccines. By using these mice, scientists can gain valuable insights into human biology and potentially develop new strategies for the prevention and treatment of human diseases.
Common Misspellings for SCID HU MICE
- acid hu mice
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