ALDOSE REDUCTASE IB Meaning and
Definition
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Aldose Reductase Ib is an enzyme that is a member of the aldo-keto reductase superfamily and is primarily found in various tissues and organs of the human body. It plays a crucial role in the metabolism of glucose and the synthesis of polyols, such as sorbitol and galactitol.
The primary function of Aldose Reductase Ib is the reduction of aldoses, which are a class of simple sugars containing an aldehyde group, into their corresponding alcohols. This enzymatic process involves the conversion of glucose into sorbitol and galactose into galactitol. By converting aldoses into polyols, Aldose Reductase Ib contributes to the detoxification of aldehydes and the regulation of intracellular osmolarity.
The overactivity of Aldose Reductase Ib has been associated with various complications related to diabetes, such as diabetic neuropathy, nephropathy, and retinopathy. Elevated levels of sorbitol and galactitol resulting from increased Aldose Reductase Ib activity can lead to cellular damage due to osmotic stress and the production of reactive oxygen species.
Pharmaceutical research has been directed towards the development of inhibitors for Aldose Reductase Ib to control the high glucose-induced accumulation of polyols and prevent or mitigate diabetic complications. These inhibitors could potentially offer therapeutic benefits for patients with diabetes by reducing the damaging effects of excess sorbitol and galactitol accumulation. Further studies are required to fully elucidate the role of Aldose Reductase Ib and its potential as a therapeutic target in various disease conditions.
Common Misspellings for ALDOSE REDUCTASE IB
- zldose reductase ib
- sldose reductase ib
- wldose reductase ib
- qldose reductase ib
- akdose reductase ib
- apdose reductase ib
- aodose reductase ib
- alsose reductase ib
- alxose reductase ib
- alcose reductase ib
- alfose reductase ib
- alrose reductase ib
- aleose reductase ib
- aldise reductase ib
- aldkse reductase ib
- aldlse reductase ib
- aldpse reductase ib
- ald0se reductase ib
- ald9se reductase ib
- aldoae reductase ib
Similar spelling words for ALDOSE REDUCTASE IB
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