ALDOSE REDUCTASE INHIBITION Meaning and
Definition
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Aldose reductase inhibition refers to the process of inhibiting the activity of the enzyme aldose reductase. Aldose reductase is an enzyme involved in the metabolism of glucose and plays a crucial role in converting glucose into sorbitol, a sugar alcohol. This enzyme is primarily present in various tissues of the body, such as the eyes, kidneys, and nerves.
Inhibition of aldose reductase is a significant pharmacological target and has been a subject of interest in the field of biomedical research. This inhibition is often sought to prevent the accumulation of sorbitol, which is implicated in various complications associated with chronic hyperglycemia, particularly in diabetes mellitus.
By inhibiting the activity of aldose reductase, the conversion of glucose to sorbitol is hindered, thereby reducing the buildup of sorbitol in cells and tissues. Since excessive sorbitol accumulation is associated with oxidative stress, inflammation, and cell damage, aldose reductase inhibition is considered a potential therapeutic strategy to mitigate or prevent diabetic complications.
In summary, aldose reductase inhibition refers to the process of inhibiting the activity of the enzyme aldose reductase to prevent the excessive accumulation of sorbitol and potentially alleviate the complications associated with chronic hyperglycemia, particularly in diabetes mellitus.
Common Misspellings for ALDOSE REDUCTASE INHIBITION
- zldose reductase inhibition
- sldose reductase inhibition
- wldose reductase inhibition
- qldose reductase inhibition
- akdose reductase inhibition
- apdose reductase inhibition
- aodose reductase inhibition
- alsose reductase inhibition
- alxose reductase inhibition
- alcose reductase inhibition
- alfose reductase inhibition
- alrose reductase inhibition
- aleose reductase inhibition
- aldise reductase inhibition
- aldkse reductase inhibition
- aldlse reductase inhibition
- aldpse reductase inhibition
- ald0se reductase inhibition
- ald9se reductase inhibition
- aldoae reductase inhibition
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